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A Melanoma Patient-Derived Xenograft Model

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Malignant acanthosis nigricans: a case report.

Xiaoyan Zhang^1,2, Rongjun Liu¹, Yiyun Liu¹

¹Department of Ophthalmology, Peking University Third Hospital, 49 North Garden Rd., Haidian District, 100191, Beijing, PR China.

BMC Ophthalmology

|November 14, 2020

Summary

This summary is machine-generated.

Malignant acanthosis nigricans, a skin condition, can manifest unusually in young patients with eyelid growths. Early detection is crucial for timely cancer diagnosis and treatment.

Keywords:

Case report Dry eye disease Gastric adenocarcinoma Malignant acanthosis nigricans

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Area of Science:

Dermatology
Oncology

Background:

Presents a rare case of malignant acanthosis nigricans.
Highlights unusual features: young patient age and eyelid margin filiform papillomas.

Observation:

A 30-year-old woman with dry eye symptoms showed widespread filiform papillomas and hyperpigmentation.
Biopsies confirmed gastric, pancreatic, and thyroid adenocarcinomas with metastasis.

Findings:

Diagnosed with malignant acanthosis nigricans associated with multiple internal malignancies.
The patient succumbed to the disease four months post-diagnosis.

Implications:

Eyelid margin acanthosis nigricans suggests underlying internal malignancy.
Emphasizes the critical need for prompt systemic investigation in suspicious cases to prevent diagnostic delays.