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Updated: Nov 30, 2025

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Long-Term Neurocognitive, Mental Health Consequences of Contact Sports
Barry S Willer1, Mohammad Nadir Haider2, Charles Wilber2
1Department of Psychiatry, Jacobs School of Medicine and Biomedical Sciences, Concussion Management Clinic and Research Center, State University of New York at Buffalo, 160 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA.
Abstract:
This article presents a brief history and literature review of chronic traumatic encephalopathy (CTE) in professional athletes that played contact sports. The hypothesis that CTE results from concussion or sub-concussive blows is based largely on several case series investigations with considerable bias. Evidence of CTE in its clinical presentation has not been generally noted in studies of living retired athletes. However, these studies also demonstrated limitation in research methodology. This paper aims to present a balanced perspective amidst a politically charged subject matter.
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