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Cardiac Involvement of COVID-19: A Comprehensive Review
Wei-Ting Chang1, Han Siong Toh2, Chia-Te Liao3
1Division of Cardiology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
Insights
Coronavirus Disease 2019 (COVID-19) significantly impacts the cardiovascular system, increasing risks for patients with existing heart conditions. This review details COVID-19
Area of Science:
- Cardiology
- Infectious Diseases
- Virology
Background:
- Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, has reached pandemic status.
- COVID-19 poses significant risks to the cardiovascular system, especially for individuals with pre-existing cardiovascular disease.
- Mortality in COVID-19 patients is strongly linked to cardiovascular disease, diabetes, and hypertension.
Purpose of the Study:
- To review the existing literature on the cardiovascular involvement of COVID-19.
- To understand the direct and indirect cardiovascular complications associated with SARS-CoV-2 infection.
- To highlight the importance of comprehending COVID-19's cardiovascular effects for patient care.
Main Methods:
- Literature review of studies on COVID-19 and cardiovascular involvement.
- Analysis of reported cardiovascular complications and impacts.
- Synthesis of findings regarding virus-host interactions in the cardiovascular system.
Main Results:
- COVID-19 patients with pre-existing cardiovascular disease face a higher risk of severe outcomes and death.
- Investigational COVID-19 therapies may lead to cardiovascular side effects like arrhythmia.
- SARS-CoV-2 infection can trigger various cardiovascular issues, including vascular inflammation, myocardial injury, myocarditis, arrhythmias, thromboembolism, and Kawasaki disease.
Conclusions:
- Understanding the multifaceted cardiovascular effects of COVID-19 is crucial for effective patient management.
- Comprehensive medical care for cardiac patients and COVID-19 patients requires awareness of potential cardiac complications.
- The review underscores the critical link between SARS-CoV-2 infection and cardiovascular health.
Abstract:
Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2 caused COVID-19 has reached a pandemic level. COVID-19 can significantly affect patients' cardiovascular systems. First, those with COVID-19 and preexisting cardiovascular disease have an increased risk of severe disease and death. Mortality from COVID-19 is strongly associated with cardiovascular disease, diabetes, and hypertension. Second, therapies under investigation for COVID-19 may have cardiovascular side effects of arrhythmia. Third, COVID-19 is associated with multiple direct and indirect cardiovascular complications. Associated with a high inflammatory burden related to cytokine release, COVID-19 can induce vascular inflammation, acute myocardial injury, myocarditis, arrhythmias, venous thromboembolism, metabolic syndrome and Kawasaki disease. Understanding the effects of COVID-19 on the cardiovascular system is essential for providing comprehensive medical care for cardiac and/or COVID-19 patients. We hereby review the literature on COVID-19 regarding cardiovascular virus involvement.
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