Cardiac Involvement of COVID-19: A Comprehensive Review

Wei-Ting Chang1, Han Siong Toh2, Chia-Te Liao3

  • 1Division of Cardiology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan.

Insights

Coronavirus Disease 2019 (COVID-19) significantly impacts the cardiovascular system, increasing risks for patients with existing heart conditions. This review details COVID-19

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, has reached pandemic status.
  • COVID-19 poses significant risks to the cardiovascular system, especially for individuals with pre-existing cardiovascular disease.
  • Mortality in COVID-19 patients is strongly linked to cardiovascular disease, diabetes, and hypertension.

Purpose of the Study:

  • To review the existing literature on the cardiovascular involvement of COVID-19.
  • To understand the direct and indirect cardiovascular complications associated with SARS-CoV-2 infection.
  • To highlight the importance of comprehending COVID-19's cardiovascular effects for patient care.

Main Methods:

  • Literature review of studies on COVID-19 and cardiovascular involvement.
  • Analysis of reported cardiovascular complications and impacts.
  • Synthesis of findings regarding virus-host interactions in the cardiovascular system.

Main Results:

  • COVID-19 patients with pre-existing cardiovascular disease face a higher risk of severe outcomes and death.
  • Investigational COVID-19 therapies may lead to cardiovascular side effects like arrhythmia.
  • SARS-CoV-2 infection can trigger various cardiovascular issues, including vascular inflammation, myocardial injury, myocarditis, arrhythmias, thromboembolism, and Kawasaki disease.

Conclusions:

  • Understanding the multifaceted cardiovascular effects of COVID-19 is crucial for effective patient management.
  • Comprehensive medical care for cardiac patients and COVID-19 patients requires awareness of potential cardiac complications.
  • The review underscores the critical link between SARS-CoV-2 infection and cardiovascular health.

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