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Updated: Aug 5, 2026

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
Combined carotid and coronary surgery
1Open Heart Surgery Unit, University of Melbourne Teaching Hospitals, St Vincent's Hospital, Victoria, Australia.
Insights
Combined carotid endarterectomy (CEA) and coronary artery bypass grafting (CABG) in high-risk patients showed a low permanent stroke rate of 2.6%. This combined procedure is a viable option for patients with severe coronary and carotid disease.
Area of Science:
- Cardiovascular Surgery
- Neurology
- Vascular Surgery
Background:
- Patients with severe coronary artery disease (CAD) and extracranial carotid stenosis often require both coronary artery bypass grafting (CABG) and carotid endarterectomy (CEA).
- The combined procedure aims to mitigate risks of myocardial infarction and cerebral ischemia in high-risk individuals.
Purpose of the Study:
- To determine the stroke rate associated with combined CEA/CABG procedures.
- To evaluate the safety and efficacy of performing CEA and CABG concurrently.
Main Methods:
- A retrospective review of 40 consecutive patients undergoing combined CEA/CABG was conducted.
- Patients had severe CAD and either signs of cerebral ischemia or asymptomatic carotid bruits.
- CEA was performed prior to CABG under a single general anesthetic.
Main Results:
- Six patients (15.4%) experienced postoperative cerebral ischemic events.
- These included reversible ischemic neurological deficit (7.7%), transient ischemic cerebral event (5.1%), and permanent stroke (2.6%).
- Two cardiac-related deaths occurred (5% mortality).
Conclusions:
- Combined CEA/CABG can be performed with a permanent stroke rate comparable to individual procedures.
- The procedure is a safe option for patients with combined coronary and carotid vascular disease at risk of infarction.
- Mortality for the combined procedure was 5%.
Abstract:
A retrospective review of 40 consecutive patients undergoing combined coronary artery bypass grafting (CABG) and unilateral carotid endarterectomy (CEA) was carried out to determine the stroke rate for the procedure. Patients presenting with severe coronary artery disease judged to be at risk of imminent myocardial infarction, who had signs of cerebral ischaemia (70%) or asymptomatic carotid bruits (30%), were investigated for extracranial carotid vascular disease. Patients with severe stenotic carotid lesions associated with high risk coronary artery disease underwent combined CEA/CABG. Three patients had a previous contralateral CEA. The average age of the patients was 62 years, and there were 31 males and nine females. CEA was completed prior to CABG under the same general anaesthetic. There were 24 CEAs on the left and 16 on the right. Six patients suffered a postoperative cerebral ischaemic event (15.4%): a reversible ischaemic neurological deficit in three (7.7%), a transient ischaemic cerebral event in two (5.1%), and a permanent stroke occurred in one (2.6%). Two deaths occurred and both were cardiac related. Combined CEA/CABG in patients with stenotic lesions of the coronary and extra-cranial carotid vascular systems who are at risk of cerebral or myocardial infarction, can be performed with a permanent stroke rate within the published range for either CEA or CABG alone and with a mortality of 5%.
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