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Updated: Nov 30, 2025

Using Microtiter Dish Radiolabeling for Multiple In Vivo Measurements Of Escherichia coli pppGpp Followed by Thin Layer Chromatography
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ppGpp functions as an alarmone in metazoa

Doshun Ito1, Hinata Kawamura1, Akira Oikawa2

  • 1Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.

Communications Biology
|November 14, 2020
PubMed
Summary

Guanosine 3',5'-bis(pyrophosphate) (ppGpp) is detected in animal cells, revealing its role in the stringent response. ppGpp accumulation in Drosophila causes metabolic changes, cell death, and lethality, establishing its physiological relevance in animals.

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