Challenges and future directions in LC-MS-based multiclass method development for the quantification of food
David Steiner1, Alexandra Malachová2, Michael Sulyok3
1FFoQSI GmbH - Austrian Competence Centre for Feed and Food Quality, Safety and Innovation, Technopark 1C, 3430, Tulln, Austria.
Analytical and Bioanalytical Chemistry
|November 14, 2020
Summary
Advanced analytical techniques now allow for the simultaneous detection of over 1000 food contaminants and residues. This multiclass approach enhances food safety monitoring by analyzing diverse chemical families together.
Area of Science:
- Analytical Chemistry
- Food Science
- Environmental Science
Background:
- Food safety monitoring has significantly advanced with new analytical technologies.
- Quantitative multi-target approaches can now detect hundreds of analytes.
- Current trends focus on simultaneous determination of multiclass contaminants and residues.
Purpose of the Study:
- To provide an overview of multiclass analytical concepts for food contaminants and residues.
- To critically discuss the merits and shortcomings of these methods based on EU legislation.
- To present a case study of a multiclass approach detecting over 1000 substances.
Main Methods:
- Liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- Liquid chromatography-high resolution mass spectrometry (LC-HRMS).
- Development of multiclass analytical methods.
Main Results:
- Multiclass approaches offer comprehensive analysis of diverse food contaminants.
- LC-MS/MS and LC-HRMS are key technologies for these methods.
- A case study demonstrates a method capable of detecting >1000 substances.
Conclusions:
- Multiclass methods represent a significant advancement in food safety monitoring.
- These techniques improve the efficiency and scope of contaminant analysis.
- Ongoing developments promise even broader coverage for food safety assurance.
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