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Localization of Ro (SS-A) antigen in the cardiac conduction system
J S Deng1, L W Bair, S Shen-Schwarz
1Department of Dermatology, Verterans Administration Medical Center, Pittsburgh, PA 15240.
Arthritis and Rheumatism
|November 1, 1987
Abstract:
The presence of anti-Ro (SS-A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti-Ro (SS-A) antibodies in an indirect immunofluorescence assay, Ro (SS-A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS-A) antigen, anti-Ro (SS-A) antibody, and heart block is discussed.