Related Experiment Video
Updated: Aug 12, 2026
09:48
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
14.1K
CTP-guided reperfusion therapy in acute ischemic stroke: a meta-analysis
Anubhav Katyal1,2, Sonu Bhaskar1,2,3,4,5
1Neurovascular Imaging Laboratory, Ingham Institute for Applied Medical Research, Clinical Sciences Stream, Sydney, NSW, Australia.
Acta Neurologica Scandinavica
|November 14, 2020
Summary
Computed tomography perfusion (CTP) imaging enhances reperfusion therapy for acute ischemic stroke (AIS) patients. CTP-guided treatment improves functional outcomes, especially with endovascular thrombectomy.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Computed tomography perfusion (CTP) is a valuable tool for guiding reperfusion therapy in acute ischemic stroke (AIS).
- Patient selection for reperfusion therapy can be optimized using CTP imaging.
- Assessing the efficacy of CTP-guided reperfusion is crucial for improving AIS management.
Purpose of the Study:
- To systematically review and meta-analyze the efficacy of CTP-guided reperfusion therapy in AIS patients.
- To determine if CTP guidance improves functional outcomes in AIS.
- To evaluate the safety profile of CTP-guided reperfusion therapy.
Main Methods:
- Systematic literature search of Medline/PubMed, Embase, and Cochrane Library.
- Inclusion criteria: original data, adult patients (≥18 years), anterior circulation AIS, good methodological design.
- Meta-analysis of data from 22 studies involving 5,687 patients.
Main Results:
- CTP-guided reperfusion therapy was associated with increased odds of a good functional outcome.
- No significant difference in the safety profile was observed between CTP-guided and standard therapy.
- The analysis included 22 studies and 5,687 patients.
Conclusions:
- CTP-guided reperfusion therapy significantly improves functional outcomes in AIS patients.
- Patients treated with endovascular thrombectomy alongside CTP guidance experienced increased benefits.
- CTP imaging is an effective strategy for optimizing reperfusion therapy in AIS.
