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A neutrophil signature is strongly associated with increased cardiovascular risk in gout

Daisy Vedder1,2, Martijn Gerritsen1, Michael T Nurmohamed1,2,3

  • 1Amsterdam Rheumatology and Immunology Center Reade, Amsterdam, The Netherlands.

Rheumatology (Oxford, England)
|November 14, 2020
PubMed

Insights

Neutrophil activation markers are elevated in gout patients and linked to cardiovascular disease risk factors. A "neutrophil activation signature" significantly increases the 10-year risk of cardiovascular mortality in gout patients.

Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Gout is associated with an increased risk of cardiovascular disease.
  • Neutrophil activation and neutrophil extracellular traps (NETs) are implicated in inflammatory processes and atherogenesis.

Purpose of the Study:

  • To investigate the association between neutrophil activation and cardiovascular risk in gout patients.
  • To determine if neutrophil activation markers correlate with cardiovascular risk factors and mortality risk.

Main Methods:

  • Analysis of neutrophil activation markers (calprotectin, peroxidase activity) and NETs in 75 gout patients and healthy controls.
  • Correlation of neutrophil activation markers with clinical cardiovascular risk factors (BMI, blood pressure, lipids) and 10-year cardiovascular mortality risk (EU-SCORE).

Main Results:

  • Gout patients showed elevated levels of neutrophil activation markers (peroxidase, calprotectin) compared to controls.
  • Peroxidase activity correlated with waist:hip ratio, cholesterol ratio, triglycerides, and 10-year cardiovascular mortality risk.
  • A 'neutrophil activation signature' (high peroxidase and calprotectin) was strongly associated with elevated cardiovascular risk and mortality risk.

Conclusions:

  • Elevated neutrophil activation markers are present in gout patients and associated with cardiovascular risk factors like hyperlipidemia, hypertension, and diabetes.
  • The 'neutrophil activation signature' is a significant predictor of increased 10-year cardiovascular mortality risk in gout patients.
  • Further research is needed to elucidate the interplay between gout, cardiovascular risk factors, and neutrophil activation.
Abstract

Keywords:
atherosclerosiscardiovascular diseasegoutinflammationneutrophils

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