Virus-like hollow mesoporous silica nanoparticles for cancer combination therapy

Virus-like nanostructures could involve their interaction with biological hosts, as well as adaptive immune responses. Herein, imitating the intrinsic structure of virus, we formulated novel virus-like hollow mesoporous silica nanoparticles (VH-MSNs) by using self-consuming perovskite template. The unique topological structure on the surface of nanoparticles could enhance cellular uptake and amplify the immune response. By loading doxorubicin (DOX) on nanoparticles, we achieved a combination of chemotherapy and immunotherapy. This study provides a promising platform with superior cellular uptake property for drug delivery and a basis for the study of the effect of surface physical structure on the nanocarriers.