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Transcriptional co-activators YAP/TAZ: Potential therapeutic targets for metastatic breast cancer

Wenxia Zhao1, Mengyan Wang1, Meilian Cai1

  • 1NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 14, 2020
PubMed

Insights

Yes-associated protein (YAP) and/or PDZ binding motif (TAZ) activation drives breast cancer metastasis. Targeting YAP/TAZ offers a promising new strategy for treating advanced breast cancer and improving patient survival rates.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Breast cancer remains a leading cause of cancer-related death in women worldwide.
  • Metastasis is the primary driver of mortality in breast cancer patients.
  • Abnormal activation of Yes-associated protein (YAP) and PDZ binding motif (TAZ) pathways is implicated in tumor progression.

Purpose of the Study:

  • To review the role of YAP/TAZ in regulating breast cancer metastasis.
  • To summarize YAP/TAZ post-translational modification mechanisms.
  • To discuss novel therapeutic strategies targeting YAP/TAZ for breast cancer treatment.

Main Methods:

  • Literature review of studies investigating YAP/TAZ in breast cancer.
  • Analysis of molecular mechanisms linking YAP/TAZ to metastasis.
  • Evaluation of current and emerging therapeutic approaches targeting YAP/TAZ.

Main Results:

  • YAP/TAZ activation promotes key metastatic processes including epithelial-mesenchymal transition, cancer stem cell generation, and drug resistance.
  • YAP/TAZ interacts with metastasis-related factors and pathways, driving cancer progression.
  • Evidence supports YAP/TAZ as a critical regulator of breast cancer metastasis.

Conclusions:

  • YAP/TAZ signaling is a significant contributor to breast cancer metastasis.
  • Targeting YAP/TAZ and its regulatory pathways presents a promising therapeutic avenue.
  • Further research into YAP/TAZ-based treatments could improve outcomes for breast cancer patients.
Keywords:
Hippo pathwayMetastatic breast cancerPost-translational modificationTargeted therapyYAP/TAZ

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