Dispersive micro-solid phase extraction combined with switchable hydrophilicity solvent-based homogeneous...

Herein, a sensitive and green method combining dispersive micro-solid phase extraction (D-μ-SPE) and homogeneous liquid-liquid microextraction (HLLME) has been developed. Magnetic layered double hydroxide nanoparticals were prepared and used as adsorbents in d-μ-SPE. The fascinating dissolvable characteristic of the material can eliminate elution step without usage of toxic organic solvents. Dipropylamine was used as a pH-triggered switchable hydrophilicity solvent that can change the miscible/immiscible states reversibly, achieving fast two-phase separation. To demonstrate the applicability of proposed method, three non-steroidal anti-inflammatory drugs including ketoprofen, naproxen and tolmetin in water samples were enriched and purified prior to HPLC-UV analysis. The influencing parameters such as pH of sample solution, amount of sorbent, vortex time, type and volume of acidic solution and SHS, volume of NaOH were optimized in detail. The method exhibits good linearity (0.1-50 ng/mL), low limits of detection (0.02-0.05 ng/mL), high precision (RSDs<9.3%) and acceptable accuracy (97.2%-105.7%). Therefore, the presented procedure is fast, sensitive, simple and suitable for determination of non-steroidal anti-inflammatory drugs from aqueous matrices.