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Updated: Nov 30, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Energy and caloric restriction, and fasting and cancer: a narrative review
Ezzeldin M Ibrahim1, Meteb H Al-Foheidi2,3, Mubarak M Al-Mansour4,5,6
1Oncology Center, International Medical Center, Jeddah, Kingdom of Saudi Arabia.
Abstract:
Dietary interventions have a significant impact on body metabolism. The sensitivity of cancer cells to nutrient and energy deficiency is an evolving characteristic of cancer biology. Preclinical studies provided robust evidence that energy and caloric restrictions could hinder both cancer growth and progression, besides enhancing the efficacy of chemotherapy and radiation therapy. Moreover, several, albeit low-powered, clinical trials have demonstrated clinical benefits in cancer patients. Future research will inform and firmly establish the potential efficacy and safety of these dietary interventions. Here, we review the current evidence and ongoing research investigating the relationship between various dietary restriction approaches and cancer outcomes.
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