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The chronic myeloid leukaemia story in the United Kingdom since 1960

Richard E Clark1

  • 1Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.

British Journal of Haematology
|November 15, 2020
PubMed

Over the past 60 years, haematologists and scientists from the United Kingdom, notably John Goldman and Tessa Holyoake, have punched above their weight in changing chronic myeloid leukaemia (CML) from an incurable and invariably fatal disease for all, to a chronic condition where over 90% have normal life expectancy. As a result, it is now difficult to power a worthwhile phase 3 study for newly diagnosed patients. Nevertheless, important clinical questions remain.

Keywords:
BCR-ABLCMLChronic myeloid leukaemiaPhiladelphia translocationimatinibtyrosine kinase inhibitors

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