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Updated: Nov 30, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo
Azin Aghamajidi1, Ehsan Raoufi2, Gilda Parsamanesh3
1Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract:
T cell-mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune-pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies.
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