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COVID-19 Infection in Men on Testosterone Replacement Therapy
Amarnath Rambhatla1, Chandler J Bronkema2, Nicholas Corsi2
1Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA.
The Journal of Sexual Medicine
|November 16, 2020
Summary
Testosterone replacement therapy (TRT) did not worsen clinical outcomes for men with COVID-19. This study found no significant differences in hospital admission, ICU stays, or death rates between men on TRT and those not on TRT.
Area of Science:
- Endocrinology
- Infectious Diseases
- Men's Health
Background:
- Men with COVID-19 (coronavirus disease 2019) exhibit poorer outcomes than women, suggesting potential androgen influence.
- Testosterone's role in COVID-19 severity is unclear.
Observation:
- A retrospective study compared 32 men with COVID-19 on TRT to 63 men with COVID-19 not on TRT.
- Propensity score matching controlled for comorbidities.
Findings:
- No statistically significant differences were observed in hospital admission, ICU admission, ventilator use, thromboembolic events, or mortality between groups.
- TRT was not a predictor of adverse outcomes in multivariate analysis.
Implications:
- Testosterone replacement therapy does not appear to be associated with worse clinical outcomes in men diagnosed with COVID-19.
- This finding may inform clinical management of male COVID-19 patients undergoing TRT.
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