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Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
Published on: January 7, 2019
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Ketogenic diets, not for everyone.
Ira J Goldberg1, Nouran Ibrahim1, Cindy Bredefeld2
1Division of Endocrinology, Diabetes and Metabolism, NYU Langone Medical Center, New York, NY, USA.
Journal of Clinical Lipidology
|November 16, 2020
Summary
Ketogenic diets can significantly raise cholesterol levels, even in individuals without pre-existing hyperlipidemia. Patients experienced marked cholesterol increases, highlighting potential risks of these popular low-carbohydrate diets.
Area of Science:
- Cardiology
- Metabolic Disorders
- Nutritional Science
Background:
- Low-carbohydrate diets, including ketogenic diets, are widely adopted for weight loss.
- These diets carry a risk of exacerbating hypercholesterolemia (high cholesterol).
Observation:
- This study examined 5 patients who developed significant increases in plasma cholesterol while on ketogenic diets.
- The patients' genetic predispositions for hyperlipidemia were assessed.
Findings:
- Three patients experienced extreme cholesterol increases (over 500 mg/dL); two others more than doubled their LDL cholesterol.
- Genetic analysis revealed APOE E2/E2 genotype in one patient and common polymorphisms in two others; no major mutations were found in two patients.
- Cholesterol levels decreased in three patients upon diet liberalization, and one patient showed improvement with ezetimibe treatment.
Implications:
- High-fat, low-carbohydrate diets can cause or worsen hypercholesterolemia, irrespective of underlying genetic predisposition.
- Clinicians should exercise caution when recommending ketogenic diets, especially in patients with or at risk for hyperlipidemia.
- Further research into genetic factors influencing dietary lipid responses is warranted.
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