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Updated: Nov 30, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
Current understanding and future implications of sepsis-induced thrombocytopenia
Subash Ghimire1, Swapna Ravi1, Rasmita Budhathoki2
1Department of Medicine, Guthrie Robert Packer Hospital, Sayre, PA, USA.
Abstract:
Sepsis is a global health burden that needs intensive medical care. Thrombocytopenia in sepsis is well known to increase morbidity as well as mortality. Several studies have been performed both in animal models and in humans to understand the mechanism by which sepsis causes thrombocytopenia. Recent studies have shown that inhibiting thrombocytopenia improves outcomes in sepsis patients. Understanding these mechanisms to identify targets in use of newer treatment modalities besides using resuscitation measures, antibiotics and removal of thrombocytopenia inducing agent could potentially help us improve outcomes in sepsis.
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