Combining Immunoscore with Clinicopathologic Features in Cholangiocarcinoma: An Influential Prognostic Nomogram

Area of Science:

• Oncology
• Immunology
• Pathology

Background:

• Cholangiocarcinoma (CCA) prognosis is complex, influenced by tumor-immune interactions.
• Accurate prediction of recurrence and survival is crucial for postoperative CCA management.

Purpose of the Study:

• To evaluate the Immunoscore as an independent prognostic factor in cholangiocarcinoma.
• To develop a predictive model for postoperative recurrence and overall survival (OS) in CCA patients.

Main Methods:

• Retrospective analysis of 76 cholangiocarcinoma patients.
• Assessed correlations between clinicopathological features, immune microenvironment, and prognosis.
• Multivariate analysis identified independent prognostic factors for local recurrence-free survival (LRFS) and OS.
• Constructed a nomogram integrating Immunoscore and clinicopathological data.

Main Results:

• Decreased Immunoscore correlated with poorer prognosis and increased immune cell infiltration.
• Immunoscore, resection type, tumor number, lymph node metastasis, and TNM staging predicted LRFS.
• Resection type, vascular invasion, TNM staging, and Immunoscore predicted OS.
• Immunoscore demonstrated superior predictive ability over TNM staging for both LRFS and OS.

Conclusions:

• The Immunoscore is a valuable independent predictor for postoperative recurrence and OS in cholangiocarcinoma.
• The Immunoscore offers advantages over the TNM staging system.
• A novel nomogram combining Immunoscore and clinicopathological features provides enhanced prognostic accuracy for CCA patients.