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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Related Experiment Video

Updated: Nov 30, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Association Between Psoriasis and Dementia: Current Evidence.

Liu Liu1,2, Si-Ting Chen1,2, Hong-Jin Li3

  • 1Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Aging Neuroscience
|November 16, 2020
PubMed
Summary

This study found that individuals with psoriasis and psoriatic arthritis have a higher prevalence of dementia. However, dementia does not appear to be a significant risk factor for death in severe psoriasis cases.

Keywords:
dementiameta-analysispsoriasispsoriatic arthritissystematic review

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Area of Science:

  • Neurology
  • Immunology
  • Public Health

Background:

  • Psoriasis and dementia are both inflammatory conditions with a poorly understood association.
  • Existing research on the link between psoriasis and dementia yields conflicting results.
  • This study aimed to clarify the relationship between psoriasis and dementia risk.

Approach:

  • A comprehensive literature search was conducted across six databases up to July 2020.
  • A meta-analysis of seven studies involving over 3.6 million participants was performed.
  • Statistical analyses, including subgroup, sensitivity, and meta-regression, were utilized to assess the association.

Key Points:

  • Patients with psoriasis and psoriatic arthritis exhibit increased proportions of non-vascular and vascular dementia.
  • A bidirectional relationship is suggested, with dementia patients being more likely to develop psoriasis.
  • Severe psoriasis was associated with a lower likelihood of death from dementia, though this requires further investigation.

Conclusions:

  • Psoriasis and psoriatic arthritis are linked to a high prevalence of various dementia types.
  • Dementia may not be a primary mortality risk factor in severe psoriasis.
  • Early identification of this association can guide interventions to mitigate comorbidities and mortality.