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Published on: May 6, 2014
Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis
Qingyu Meng1, Luya Pu1, Xizi Luo1
1Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University, Changchun, China.
Insights
Long non-coding RNAs (lncRNAs) play a crucial role in atherosclerosis development. This review explores how lncRNAs regulate key processes in this vascular disease, highlighting their therapeutic potential.
Area of Science:
- Molecular Biology
- Cardiovascular Research
- Genetics
Background:
- Atherosclerosis (AS) is a primary cause of cardiovascular diseases, characterized by lipid deposition and inflammation in blood vessels.
- The precise molecular mechanisms driving AS pathogenesis remain incompletely understood.
- Non-coding RNAs, particularly long non-coding RNAs (lncRNAs), are emerging as critical regulators in AS.
Purpose of the Study:
- To review the current understanding of lncRNAs' roles in atherosclerosis.
- To elucidate the regulatory functions of lncRNAs in key atherosclerotic processes.
- To highlight the therapeutic potential of lncRNAs for vascular diseases.
Main Methods:
- Literature review of studies on lncRNAs and atherosclerosis.
- Analysis of lncRNA regulatory mechanisms in AS progression.
- Synthesis of current knowledge on lncRNA involvement in lipid metabolism, inflammation, and cell dynamics.
Main Results:
- lncRNAs significantly influence multiple stages of atherosclerotic progression.
- Specific lncRNAs regulate lipid metabolism, inflammation, vascular cell proliferation, apoptosis, migration, and angiogenesis.
- lncRNAs are implicated in the complex molecular pathways underlying AS.
Conclusions:
- lncRNAs are critical regulators of atherosclerosis.
- Understanding lncRNA functions offers insights into AS pathogenesis.
- lncRNAs represent promising novel therapeutic targets for treating vascular diseases.
Abstract:
Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease, which comprise serious hazards to human health. Atherosclerosis is characterized by the deposition of lipids on the interior walls of blood vessels, causing an inflammatory response of immune cells, endothelial cells, and smooth muscle cells, and a proliferation cascade reaction. Despite years of research, the underlying pathogenesis of AS is not fully defined. Recent advances in our understanding of the molecular mechanisms by which non-coding RNA influences the initiation and progression of AS have shown that long non-coding RNAs (lncRNAs) regulate important stages in the atherosclerotic process. In this review, we summarize current knowledge of lncRNAs, which influence the development of AS. We review the regulatory processes of lncRNAs on core stages of atherosclerotic progression, including lipid metabolism, inflammation, vascular cell proliferation, apoptosis, adhesion and migration, and angiogenesis. A growing body of evidence suggests that lncRNAs have great potential as new therapeutic targets for the treatment of vascular diseases.
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