Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure-activity relations in carcinogenesis by N-nitroso compounds.

W Lijinsky1

  • 1BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, MD 21701.

Cancer Metastasis Reviews
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of deuterium on the carcinogenicity of nitroso-methyl-n-butylamine.

Carcinogenesis·2012
Same author

Agricultural pesticide use and risk of glioma in Nebraska, United States.

Occupational and environmental medicine·2005
Same author

Agricultural pesticide use and adenocarcinomas of the stomach and oesophagus.

Occupational and environmental medicine·2004
Same author

N-Nitroso compounds in the diet.

Mutation research·1999
Same author

Response to the June 13, 1996, draft report of the Commission on Risk Assessment and Risk Management.

Archives of environmental health·1998
Same author

Studies of initiation and promotion of carcinogenesis by N-nitroso compounds.

Cancer letters·1998

Carcinogenic effects of N-nitroso compounds differ significantly between rats and hamsters, with distinct tumor types and target organs observed. Administration route and dosing schedule also influence tumor responses in these animal models.

Area of Science:

  • Toxicology
  • Carcinogenesis
  • Comparative Oncology

Background:

  • N-nitroso compounds encompass a broad class of chemicals with varying carcinogenic potentials.
  • Understanding species-specific responses to N-nitroso compounds is crucial for risk assessment.

Purpose of the Study:

  • To compare the carcinogenic effects of various N-nitroso compounds in rats and Syrian golden hamsters.
  • To investigate how metabolic activation and administration routes influence tumor development.

Main Methods:

  • Equimolar doses of N-nitroso compounds were administered orally to rats and hamsters.
  • Comparison of tumor types and target organs induced by nitrosamines and nitrosoalkylamides.
  • Evaluation of continuous versus pulsed dosing strategies.

Related Experiment Videos

Main Results:

  • Significant differences in tumor responses and induced tumor types were observed between rats and hamsters.
  • Nitrosamines and nitrosoalkylamides exhibited distinct target organ specificities.
  • Continuous dosing was generally more effective for nitrosamines, while pulsed dosing was more effective for nitrosoalkylureas.

Conclusions:

  • Species-specific differences in carcinogenicity of N-nitroso compounds are pronounced.
  • Metabolic activation and administration route critically affect N-nitroso compound-induced carcinogenesis.
  • Target organ specificity is linked to the generation of similar active moieties from related N-nitroso compounds.