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Endocrine Evaluation in POEMS Syndrome: A Cohort Study
Hongbo Yang1, Hao Zhao2, Xuemin Gao2
1Department of Endocrinology, Key laboratory of Endocrinology of National Health Commission, The Translational Medicine Center of PUMCH, Beijing, China.
Frontiers in Endocrinology
|November 16, 2020
Summary
Endocrinopathy, including hypothyroidism, is common in POEMS syndrome. Thyroid function improves with treatment, but baseline hypothyroidism indicates poorer survival outcomes.
Area of Science:
- Endocrinology
- Hematology
- Oncology
Background:
- POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) frequently involves endocrinopathy.
- Previous understanding of endocrine response to POEMS syndrome treatments was limited.
Purpose of the Study:
- To investigate endocrine characteristics in POEMS syndrome patients.
- To evaluate thyroid function response to different treatment regimens.
- To determine the prognostic impact of baseline endocrine dysfunction on survival.
Main Methods:
- Retrospective analysis of 383 newly diagnosed POEMS syndrome patients.
- Assessment of endocrine function (thyroid, adrenal, prolactin, gonadal) at baseline and post-treatment.
- Comparison of treatment outcomes (progression-free survival, overall survival) based on baseline endocrine status.
Main Results:
- Hypothyroidism (overt and subclinical) affected 56.6% of patients.
- Hyperprolactinemia (62.7%) and hypogonadism (48.0% in females, 22.6% in males) were prevalent.
- Thyroid function significantly improved post-treatment, irrespective of regimen, and correlated with risk stratification.
- Baseline hypothyroidism was associated with significantly inferior progression-free survival (PFS) and overall survival (OS).
Conclusions:
- Hypothyroidism, hyperprolactinemia, and hypogonadism are common in POEMS syndrome.
- Thyroid function improves with treatment and relates to risk stratification.
- Baseline hypothyroidism is a negative prognostic factor for PFS and OS in POEMS syndrome.
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