Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myeloid-T cell proximity is prominent in healthy pregnancies with extreme fetal-maternal HLA incompatibility.

iScience·2026
Same author

Assessment of genetically modified maize MON 87460 for renewal authorisation under Regulation (EC) No 1829/2003 (dossier GMFF-2023-21251).

EFSA journal. European Food Safety Authority·2025
Same author

Assessment of genetically modified maize DP202216 × NK603 × DAS-40278-9 (application GMFF-2022-6232).

EFSA journal. European Food Safety Authority·2025
Same author

Assessment of genetically modified cotton T304-40 × GHB119 × COT102 (application EFSA-GMO-BE-2018-155).

EFSA journal. European Food Safety Authority·2025
Same author

Assessment of genetically modified cotton GHB614 × T304-40 × GHB119 × COT102 (application EFSA-GMO-ES-2017-147).

EFSA journal. European Food Safety Authority·2025
Same author

Assessment of genetically modified maize NK603 × T25 for renewal authorisation under Regulation (EC) No 1829/2003 (dossier GMFF-2023-21252).

EFSA journal. European Food Safety Authority·2025

Related Experiment Video

Updated: Nov 30, 2025

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

13.9K

Visualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry.

Anita van der Zwan1, Vincent van Unen1,2, Guillaume Beyrend1

  • 1Department of Immunology, Leiden University Medical Center, Leiden, Netherlands.

Frontiers in Immunology
|November 16, 2020
PubMed
Summary

This study reveals the dynamic immune cell landscape at the maternal-fetal interface during pregnancy. Understanding this complex immune microenvironment is crucial for healthy gestation and identifying pregnancy complications.

Keywords:
deciduahuman atlasimmune profilingperipheral bloodplacentapregnancy

More Related Videos

Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

16.5K
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

17.7K

Related Experiment Videos

Last Updated: Nov 30, 2025

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

13.9K
Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

16.5K
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

17.7K

Area of Science:

  • Immunology
  • Reproductive Biology
  • Cellular Biology

Background:

  • Maintaining immunological tolerance at the maternal-fetal interface is vital for healthy pregnancy.
  • Previous research focused on specific immune cells, lacking a system-wide view of the decidual immune microenvironment.

Purpose of the Study:

  • To comprehensively profile the immune cell composition of the decidua throughout gestation using an unbiased approach.
  • To compare the decidual immune landscape with maternal peripheral blood.

Main Methods:

  • Mass cytometry was employed for in-depth immune profiling of leukocytes from first, second, and third-trimester decidua.
  • Leukocytes from maternal peripheral blood at delivery were also analyzed for comparison.

Main Results:

  • The maternal-fetal interface exhibits a unique immune cell composition distinct from peripheral blood.
  • Significant differences in immune cell populations were observed between early and term pregnancy samples.
  • Decidual immune cells display substantial heterogeneity, forming gestational-specific immune networks and differentiation pathways.

Conclusions:

  • This research provides a detailed human atlas of the maternal-fetal immune microenvironment across gestation.
  • This atlas serves as a foundation for understanding immune alterations in pregnancy complications.