Related Experiment Video

Updated: Nov 30, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

720

MicroRNAs in Podocyte Injury in Diabetic Nephropathy

Hiroki Ishii1, Shohei Kaneko1, Katsunori Yanai1

  • 1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Frontiers in Genetics
|November 16, 2020
PubMed

Insights

MicroRNAs (miRNAs) are key regulators of podocyte injury in diabetic nephropathy. This review explores their potential as diagnostic biomarkers and therapeutic targets for this diabetes complication.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Diabetic nephropathy is a leading cause of end-stage renal disease, driven by podocyte injury.
  • The molecular mechanisms regulating podocyte injury in diabetes remain incompletely understood.
  • MicroRNAs (miRNAs) are implicated in cellular processes and disease development.

Purpose of the Study:

  • To review the role of miRNAs in podocyte injury within diabetic nephropathy.
  • To evaluate the potential of miRNAs as biomarkers for diabetic nephropathy.
  • To discuss miRNA modulation as a therapeutic strategy for diabetic nephropathy.

Main Methods:

  • Literature review of studies on miRNAs in diabetic nephropathy.
  • Analysis of research on miRNA expression in diabetic podocytes (in vitro and in vivo).
  • Examination of studies investigating miRNA biomarker potential and therapeutic modulation.

Main Results:

  • Altered miRNA expression is observed in podocytes under high glucose conditions and in diabetic nephropathy models.
  • miRNA expression levels correlate with podocyte injury in patients with diabetic nephropathy.
  • Modulating specific miRNAs demonstrates protective effects against podocyte injury in experimental models.

Conclusions:

  • miRNAs play a significant role in the pathogenesis of podocyte injury in diabetic nephropathy.
  • miRNAs hold promise as non-invasive biomarkers for early detection and monitoring of diabetic nephropathy.
  • Targeted miRNA-based therapies represent a potential future treatment strategy for diabetic nephropathy.
Keywords:
biomarkerdiabetic mellitusepigeneticsmicroRNApodocyte injury

More Related Videos

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.2K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

477

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
5.9K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
293
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
5.3K