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Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers

Dong-Li Zhu1,2,3, Xiao-Mei Tuo2, Yu Rong2

  • 1Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Trauma Surgery, Honghui Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China.

Journal of Cancer
|November 16, 2020
PubMed

Insights

Fibroblast growth factor receptor (FGFR) signaling pathway alterations are common in female reproductive cancers. Targeting FGFR offers a promising avenue for novel therapies in ovarian, cervical, and endometrial cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ovarian, cervical, and endometrial cancers have poor prognoses despite advances in detection and treatment.
  • Novel therapeutic strategies are needed for these gynecologic malignancies, particularly in the era of personalized medicine.
  • The fibroblast growth factor receptor (FGFR) signaling pathway is implicated in various human cancers.

Purpose of the Study:

  • To review the role of the FGFR pathway in female reproductive system cancers.
  • To summarize genetic alterations in FGF/FGFR related to these cancers.
  • To discuss current and developing FGFR-targeted therapies for gynecologic cancers.

Main Methods:

  • Literature review of studies on FGFR signaling in female reproductive cancers.
  • Analysis of genetic alterations and mutations in FGF/FGFR.
  • Examination of available and investigational FGFR inhibitors.

Main Results:

  • FGF/FGFR pathway alterations are frequently observed in ovarian, cervical, and endometrial cancers.
  • Specific genetic mutations and amplifications in FGF/FGFR contribute to tumorigenesis.
  • Several FGFR inhibitors are in clinical development for these cancers.

Conclusions:

  • FGFR signaling represents a critical therapeutic target for female reproductive system cancers.
  • Targeted inhibition of FGFR may improve treatment efficacy and patient outcomes.
  • Further research into FGFR-targeted therapies is warranted for gynecologic malignancies.
Keywords:
Female reproductive system cancerFibroblast growth factorFibroblast growth factor receptorGenetic variationsTherapeutic targets

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