Selection of appropriate antifungal therapy

Area of Science:

• Ophthalmology
• Mycology
• Infectious Diseases

Background:

• Fungal keratitis remains a significant cause of corneal blindness worldwide.
• Despite a lack of novel antifungal agents, advancements in understanding disease mechanisms and treatment options have improved patient outcomes.

Purpose of the Study:

• To provide a comprehensive review of current therapeutic strategies for fungal keratitis.
• To discuss the role of epidemiology, pathology, and available antifungal agents in managing this infection.

Main Methods:

• Literature review focusing on epidemiology, pathology, and treatment of fungal keratitis.
• Analysis of the pharmacology and pharmacokinetics of existing antifungal medications.
• Evaluation of surgical interventions for severe cases.

Main Results:

• Management of fungal keratitis has improved due to a deeper understanding of the disease.
• Current therapeutic approaches involve a combination of antifungal agents and surgical interventions.
• The choice of treatment is guided by causative organisms and drug properties.

Conclusions:

• While new antifungal drugs are lacking, optimized use of existing therapies and surgical techniques enhances fungal keratitis management.
• A thorough understanding of causative fungi and antifungal drug profiles is crucial for effective treatment.
• Integrated management strategies are key to improving outcomes for patients with fungal keratitis.