Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

193
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
193
Vascular Spasm01:16

Vascular Spasm

2.9K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
2.9K
Spinal Cord01:26

Spinal Cord

924
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
924
Bone Disorders01:29

Bone Disorders

4.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.9K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

177
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
177
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

2.9K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abnormal eye movements increase as motor disabilities and cognitive impairments become more evident in Multiple Sclerosis: A novel eye-tracking study.

Multiple sclerosis journal - experimental, translational and clinical·2024
Same author

Clinical impact of gender and age at onset on disease trajectory in primary progressive multiple sclerosis patients.

Multiple sclerosis (Houndmills, Basingstoke, England)·2024
Same author

Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry.

Multiple sclerosis journal - experimental, translational and clinical·2023
Same author

Frequency of new asymptomatic MRI lesions during attacks and follow-up of patients with NMOSD in a real-world setting.

Multiple sclerosis (Houndmills, Basingstoke, England)·2023
Same author

Achieving no evidence of disease activity-3 in highly active multiple sclerosis patients treated with cladribine and monoclonal antibodies.

Multiple sclerosis journal - experimental, translational and clinical·2023
Same author

Frequency of NMOSD misdiagnosis in a cohort from Latin America: Impact and evaluation of different contributors.

Multiple sclerosis (Houndmills, Basingstoke, England)·2022

Related Experiment Video

Updated: Nov 30, 2025

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

238

Marchiafava-Bignami Disease Associated with Spinal Involvement.

Jhon Perea1, María Belén Luis1, Luciana Grimanesa Lázaro1

  • 1Department of Neurology, Sanatorio Güemes-University Hospital, Buenos Aires, Argentina.

Case Reports in Neurological Medicine
|November 16, 2020
PubMed
Summary

Marchiafava-Bignami disease (MBD), a rare corpus callosum disorder, can occur without alcoholism. This case highlights MBD presenting atypically, emphasizing the need for broader diagnostic considerations in neurological impairment.

More Related Videos

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.9K
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

5.2K

Related Experiment Videos

Last Updated: Nov 30, 2025

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

238
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.9K
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

5.2K

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Marchiafava-Bignami disease (MBD) is a rare neurological disorder.
  • It is typically associated with chronic alcoholism and malnutrition.
  • MBD primarily affects the corpus callosum, leading to severe neurological deficits.

Observation:

  • A 54-year-old male presented with altered consciousness and neurological impairment.
  • He had no history of alcoholism or known malabsorption.
  • Magnetic resonance imaging (MRI) revealed characteristic corpus callosum lesions.

Findings:

  • The patient exhibited complex B vitamin deficiency.
  • Clinical and radiological findings suggested concurrent spinal cord involvement.
  • Brain histopathology confirmed Marchiafava-Bignami disease.

Implications:

  • This case expands the known clinical spectrum of MBD.
  • It underscores the importance of considering MBD in non-alcoholic patients with neurological symptoms.
  • Despite treatment, the patient experienced a poor outcome, indicating the severity of the disease.