Molecular Profiling-Based Precision Medicine in Cancer: A Review of Current Evidence and Challenges

Area of Science:

• Oncology
• Genomics
• Precision Medicine

Background:

• Next-generation sequencing (NGS) guides targeted therapy in advanced solid tumors.
• The large-scale clinical benefit of NGS-guided matched therapy is not yet established.
• Limited randomized trials exist, necessitating a review of current evidence.

Purpose of the Study:

• To review and summarize data on the efficacy of NGS-guided matched therapy.
• To discuss ongoing clinical trials in this field.
• To identify limitations and challenges of this treatment strategy.

Main Methods:

• Literature review of clinical studies on NGS-guided matched therapy.
• Summary of existing data on treatment efficacy.
• Inclusion of information on ongoing trials.

Main Results:

• Current evidence for NGS-guided matched therapy is promising but not definitive.
• Multiple ongoing clinical trials are investigating this approach.
• Key challenges include sample selection, target identification, result interpretation, and drug accessibility.

Conclusions:

• NGS-guided matched therapy holds potential but requires further validation.
• Addressing implementation challenges is crucial for future clinical trial design and application.
• Enhanced focus on unsolved problems will advance precision cancer treatment.