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Long Noncoding RNAs, New Critical Regulators in Cancer Immunity
Minjie Wu1,2, Peifen Fu1, Lei Qu2
1Breast Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Frontiers in Oncology
|November 16, 2020
Summary
Long noncoding RNAs (lncRNAs) are key regulators of the immune system, especially in cancer immunity. This review details their roles in the cancer immunity cycle, offering insights for cancer diagnosis and therapies.
Area of Science:
- Molecular Biology
- Immunology
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) are integral to cellular functions.
- Emerging evidence highlights lncRNAs' critical role in immune system modulation.
- Their specific involvement in cancer immunity warrants systematic investigation.
Purpose of the Study:
- To systematically review the involvement of lncRNAs in the cancer immunity cycle.
- To elucidate the functions of lncRNAs in immune cell differentiation, proliferation, trafficking, and infiltration within the tumor microenvironment.
- To identify current limitations and future directions in understanding lncRNA functions in cancer immunity.
Main Methods:
- Systematic literature review and synthesis of existing research on lncRNAs and cancer immunity.
- Analysis of lncRNA involvement across key stages of the cancer immunity cycle.
- Discussion of challenges in studying lncRNA functions in complex biological systems.
Main Results:
- lncRNAs significantly modulate immune cell differentiation and function in cancer.
- lncRNAs influence immune cell trafficking and infiltration into tumors.
- The complex interplay between lncRNAs, the immune system, and cancer presents research challenges.
Conclusions:
- lncRNAs are pivotal in regulating cancer immunity.
- A comprehensive understanding of lncRNA functions is essential for advancing cancer diagnosis and therapeutic strategies.
- Further research is needed to overcome current limitations in the field.
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