Related Experiment Video
Updated: Nov 30, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
528
Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based Study
Liangjun Tao1, Xinyuan Pan2, Lixiang Zhang3
1Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, China.
Frontiers in Oncology
|November 16, 2020
Summary
Marital status impacts overall survival in distant-metastatic bladder cancer (DMBC) patients. A new nomogram aids in predicting survival and guiding treatment for these individuals.
Area of Science:
- Oncology
- Biostatistics
- Public Health
Background:
- Marital status is a potential social determinant of health.
- Its impact on survival in advanced cancers is not fully understood.
- Distant-metastatic bladder cancer (DMBC) presents a significant survival challenge.
Purpose of the Study:
- To assess the association between marital status and overall survival (OS) in DMBC patients.
- To develop and validate a prognostic nomogram for predicting OS in DMBC.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database (2010-2015).
- Employed Kaplan-Meier analysis for survival comparisons across marital statuses.
- Constructed a prognostic nomogram using Cox regression, validated with calibration plots and C-index.
Main Results:
- Marital status significantly influenced OS in all DMBC patients, as well as in males and females separately.
- Marital status was identified as an independent prognostic factor, though with a small contribution.
- The developed nomogram, incorporating seven factors, achieved a C-index of 0.722 for OS prediction.
Conclusions:
- Marital status is an independent prognostic factor for OS in DMBC patients.
- A validated prognostic nomogram can aid in individualized survival prediction and treatment planning for DMBC.
- Further research may explore mechanisms linking social factors to cancer outcomes.
