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Updated: Nov 30, 2025

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
Transcranial Direct Current Stimulation in the Treatment of Subacute Post-Stroke Thalamic Aphasia
William Campanella1,2, Riccardo Pedrini1,2, Lucilla Vestito1
1IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Background:
Although many studies have demonstrated the effectiveness of transcranial direct current stimulation (tDCS) in improving speech recovery in post-stroke aphasia, as far as we know patients affected by thalamic aphasia have never been investigated.
Patient And Method:
A 65-year-old man with severe non-fluent aphasia due to a left thalamic haemorrhagic stroke underwent intensive daily speech therapy combined with tDCS.
Results:
The patient showed progressive improvement with almost complete recovery of his speech disorder, behavioural disinhibition and apathy.
Conclusions:
Our findings suggest that tDCS with concurrent speech therapy can be useful in patients with subcortical stroke lesions.
Learning Points:
The thalamus has a central role in the development of the higher functions, such as memory, regulation of behaviour and emotions, and language elaboration.Transcranial direct current stimulation (tDCS) applied to the cerebral cortex is a promising tool for improving language recovery in patients with post-stroke aphasia.Combined treatment with tDCS and speech and language therapy (SLT) was effective in a patient with subacute thalamic aphasia, who showed improvement in all aspects of linguistic and behavioural communication.
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