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Clinical Findings of COVID-19 Patients Admitted to Intensive Care Units in Guangdong Province, China: A Multicenter,

Yonghao Xu1, Zhiheng Xu1, Xuesong Liu1

  • 1State Key Laboratory of Respiratory Diseases, Department of Critical Care Medicine, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Frontiers in Medicine
|November 16, 2020
PubMed

Insights

Critically ill coronavirus disease 2019 (COVID-19) patients in Guangdong Province experienced fever, lymphopenia, and organ dysfunction. Intensive care unit (ICU) mortality was low, with 4.4% 60-day mortality observed in this study.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pulmonology

Background:

  • Limited data exists on critically ill coronavirus disease 2019 (COVID-19) patients outside of Wuhan, China.
  • This study focuses on patients admitted to the intensive care unit (ICU) in Guangdong Province.

Purpose of the Study:

  • To describe the clinical characteristics, treatments, and outcomes of COVID-19 patients in Guangdong Province ICUs.
  • To compare outcomes between intubated and non-intubated COVID-19 patients.

Main Methods:

  • A multicenter, retrospective, observational study.
  • Inclusion of consecutive COVID-19 patients admitted to seven ICUs in Guangdong Province.
  • Collection of demographic, clinical, laboratory, comorbidity, treatment, and outcome data.

Main Results:

  • 45 COVID-19 patients required ICU admission (mean age 56.7 years, 64.4% male).
  • Common symptoms included fever and cough; laboratory findings showed lymphopenia and elevated lactate dehydrogenase.
  • High rates of acute respiratory distress syndrome (80%) and septic shock (33.3%) were observed. 44.4% required intubation, 22.2% received ECMO.
  • The 60-day mortality rate was 4.4%.

Conclusions:

  • COVID-19 ICU patients commonly presented with fever, lymphopenia, acute respiratory failure, and multiple organ dysfunction.
  • The observed mortality rate in Guangdong Province ICUs was relatively low.
  • Findings highlight the severe manifestations of COVID-19 in critically ill patients.

Keywords:
COVID-19SARS-CoV-2critically illintensive care unitmortality

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