Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polytherapy, monotherapy, and carbamazepine.

E H Reynolds1

  • 1University Department of Neurology, Institute of Psychiatry and Kings College Hospital Medical School, London, England.

Epilepsia
|January 1, 1987
PubMed
Summary

Monotherapy effectively controls epilepsy in about 75% of new patients, offering advantages over polytherapy. Carbamazepine is a preferred monotherapy due to fewer adverse effects on cognition and behavior.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anglo-French neurological interactions in the 19th and early 20th centuries: Societies and Journals.

Revue neurologique·2022
Same author

Anglo-French neurological interactions in the 19th and early 20th centuries: Physicians, places and events.

Revue neurologique·2021
Same author

Allbutt of Leeds and Duchenne de Boulogne: Newly discovered insights on Duchenne by a British neuropsychiatrist.

Revue neurologique·2018
Same author

A brief history of hysteria: From the ancient to the modern.

Handbook of clinical neurology·2016
Same author

What is the safe upper intake level of folic acid for the nervous system? Implications for folic acid fortification policies.

European journal of clinical nutrition·2016
Same author

Kinnier Wilson's French connections.

Revue neurologique·2014

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Polytherapy is common in epilepsy treatment but lacks evidence of superiority over monotherapy.
  • Polytherapy can cause cognitive/behavioral changes and worsen epilepsy.
  • Monotherapy offers a potentially safer and effective alternative.

Purpose of the Study:

  • To evaluate the efficacy and safety of epilepsy monotherapy compared to polytherapy.
  • To explore the potential of monotherapy in preventing drug-resistant epilepsy.
  • To identify antiepileptic drugs with favorable side effect profiles for monotherapy.

Main Methods:

  • Review of recent studies on epilepsy treatment.
  • Analysis of clinical and psychometric data on antiepileptic drugs.
  • Comparison of monotherapy and polytherapy outcomes in newly diagnosed and chronic epilepsy patients.

Main Results:

  • Approximately 75% of newly diagnosed epilepsy patients achieve 2-year remission with monotherapy.
  • Reducing polytherapy to monotherapy can improve cognitive function without increasing seizures.
  • No single antiepileptic drug shows superiority for specific seizure types.
  • Carbamazepine demonstrates fewer adverse effects on cognitive function, mood, and behavior.

Conclusions:

  • Carefully monitored monotherapy is effective for many epilepsy patients.
  • Monotherapy may help prevent the development of chronic, drug-resistant epilepsy.
  • Carbamazepine is a favorable choice for monotherapy due to its cognitive and behavioral safety profile.

Related Experiment Videos