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Estrogens and development.

J A McLachlan1, R R Newbold

  • 1National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.

Environmental Health Perspectives
|November 1, 1987
PubMed
Summary
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Female sex hormones like estrogen influence mammalian genital development. Exposure to diethylstilbestrol (DES), a potent estrogen, causes lasting effects, highlighting environmental chemical risks.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Environmental Health

Background:

  • Mammalian genital organ development is regulated by hormones.
  • The specific role of estrogen in normal genital development remains incompletely understood.
  • Environmental chemicals with estrogenic activity pose potential risks.

Purpose of the Study:

  • To investigate the unclear role of estrogen in mammalian genital development.
  • To examine the persistent differentiation effects of exogenous estrogen exposure, specifically diethylstilbestrol (DES).
  • To consider the implications of weakly estrogenic environmental chemicals on development.

Main Methods:

  • Review of existing literature on hormonal control of genital development.
  • Analysis of studies detailing the effects of diethylstilbestrol (DES) exposure in experimental animals and humans.

Related Experiment Videos

  • Consideration of the impact of environmental estrogens.

    • Main Results:

    • Estrogen's precise role in normal genital development requires further clarification.
    • Exposure to the potent synthetic estrogen diethylstilbestrol (DES) leads to persistent and significant differentiation effects.
    • Weakly estrogenic environmental compounds may also influence developmental processes.

    Conclusions:

    • Hormonal regulation is critical for mammalian genital development.
    • Diethylstilbestrol (DES) serves as a model for potent estrogen-induced developmental alterations.
    • Environmental exposure to estrogenic substances warrants consideration for potential impacts on reproductive health and development.