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Related Experiment Video

Updated: Nov 30, 2025

Extraction and Analysis of Cortisol from Human and Monkey Hair
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Measuring Earwax Cortisol Concentration using a non-stressful sampling method.

Andres Herane-Vives1,2, Lorena Ortega3, Rodrigo Sandoval3

  • 1Institute of Cognitive Neuroscience, University College London, UK.

Heliyon
|November 16, 2020
PubMed
Summary
This summary is machine-generated.

A novel earwax self-sampling device offers a more accurate method for measuring chronic cortisol concentration compared to hair samples. This non-invasive technique minimizes confounding factors, providing a reliable assessment of long-term cortisol levels.

Keywords:
Biological psychiatryDepressionEarwax cortisolEndocrine systemEndocrinologyHair cortisolMetabolismPsychiatrySelf-sampling earwax deviceSerum cortisol

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Area of Science:

  • Endocrinology
  • Biomedical Science
  • Analytical Chemistry

Background:

  • Traditional methods like hair analysis for chronic cortisol concentration are problematic due to confounding factors.
  • Short-term samples are insufficient for reflecting long-term cortisol levels.
  • Earwax offers a potential alternative for accurate, long-term cortisol measurement.

Purpose of the Study:

  • To evaluate the efficacy of a novel earwax self-sampling device for measuring chronic cortisol concentration.
  • To compare cortisol levels in earwax, hair, and serum.
  • To assess the influence of confounding factors on different sample types.

Main Methods:

  • Cortisol concentration was measured in earwax (ECC), hair (HCC), and serum (SCC) from 37 controls.
  • Earwax was collected using a standard procedure and a novel self-sampling device.
  • Correlations between sample types and the effect of confounders were analyzed.

Main Results:

  • Serum cortisol levels were highest, while hair cortisol levels were lowest.
  • Earwax collected via the novel self-sampling device was unaffected by confounding factors.
  • A moderate correlation was observed between self-sampled earwax cortisol and hair cortisol.

Conclusions:

  • The novel earwax self-sampling device provides a reliable measure of chronic cortisol concentration.
  • Earwax cortisol measurement is less susceptible to confounding factors than other methods.
  • This method presents an accurate, suitable, and affordable option for assessing long-term cortisol levels.