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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
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Coagulation factor VIII, white matter hyperintensities and cognitive function: Results from the Cardiovascular Health
Jessica L Rohmann1,2, W T Longstreth3,4, Mary Cushman5
1Charité -Universitätsmedizin Berlin, Center for Stroke Research Berlin, Berlin, Germany.
Plos One
|November 16, 2020
Summary
Higher Factor VIII clotting activity (FVIII:C) showed no strong association with white matter hyperintensities (WMH) or cognitive decline in older adults. This large cohort study found no significant link between FVIII:C levels and brain health over time.
Area of Science:
- Neurology
- Hematology
- Gerontology
Background:
- White matter hyperintensities (WMH) are common in older adults and linked to cognitive impairment.
- Factor VIII clotting activity (FVIII:C) is a marker of coagulation, and its role in cerebrovascular health is under investigation.
Purpose of the Study:
- To investigate the relationship between high FVIII:C levels, MRI-defined WMH, and cognitive function over time in older adults.
Main Methods:
- Utilized data from the Cardiovascular Health Study (n=5,888, aged ≥65).
- Assessed FVIII:C from blood samples, WMH burden from serial MRIs, and cognitive function annually (3MSE, DSST).
- Employed regression models for cross-sectional and longitudinal analyses, adjusting for demographic and cardiovascular factors.
Main Results:
- Higher FVIII:C was not strongly associated with baseline WMH burden (OR>p75 = 1.20) or WMH worsening over time (OR>p75 = 1.18).
- High FVIII:C showed no significant association with cognitive scores cross-sectionally (3MSE>p75 β = -0.06; DSST>p75 β = -0.69) or longitudinally (3MSE>p75 β = -0.07; DSST>p75 β = -0.22).
Conclusions:
- This cohort study indicates no strong relationships between higher FVIII:C levels and WMH burden or cognitive function in older adults.
- Findings suggest FVIII:C may not be a significant predictor of cerebrovascular changes or cognitive decline in this population.
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