Related Experiment Video
Updated: Nov 30, 2025

05:53
The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
Published on: August 16, 2018
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Generation of Closed Transverse Fractures in Small Animals
Anthony De Giacomo1,2, Elise F Morgan2,3, Louis C Gerstenfeld4
1Department of Orthopedic Surgery, Woodland Hills Medical Center, Woodland Hills, CA, USA.
Methods in Molecular Biology (Clifton, N.J.)
|November 16, 2020
Abstract:
The most common procedure that has been developed for use in rats and mice to model fracture healing is described. The nature of the regenerative processes that may be assessed and the types of research questions that may be addressed with this model are briefly outlined. The detailed surgical protocol to generate closed simple transverse fractures is presented and general considerations when setting up an experiment using this model are described.

