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Glucose tolerance studies in lichen planus
P K Nigam1, L Sharma, J K Agrawal
1Department of Dermato-Venereology and Leprology, Banaras Hindu University, Varanasi, India.
Dermatologica
|January 1, 1987
Summary
Lichen planus patients frequently exhibit abnormal glucose tolerance and insulin responses, mirroring patterns seen in type II diabetes. This suggests a potential link between glucose intolerance and lichen planus, though not correlated with lesion characteristics.
Area of Science:
- Endocrinology
- Dermatology
- Metabolic Syndrome
Background:
- Lichen planus is an inflammatory condition affecting skin and mucous membranes.
- Previous research suggests potential metabolic disturbances in lichen planus patients.
Purpose of the Study:
- To investigate glucose tolerance and insulin response in patients with lichen planus.
- To explore potential correlations between metabolic abnormalities and clinical features of lichen planus.
Main Methods:
- Oral glucose tolerance testing was performed on 56 patients with histologically confirmed lichen planus.
- Insulin and glucose levels were measured and analyzed.
- Insulin/glucose ratios were calculated and compared to controls.
Main Results:
- 30.3% of lichen planus patients demonstrated abnormal glucose tolerance.
- The insulin response pattern and insulin/glucose ratio were comparable to those observed in type II diabetes.
- No significant correlation was found between glucose tolerance abnormalities and the duration or distribution of lichen planus lesions.
Conclusions:
- The study reinforces the possibility of glucose intolerance in individuals with lichen planus.
- Metabolic alterations in lichen planus patients may share similarities with type II diabetes.
- Further research is warranted to elucidate the underlying mechanisms and clinical implications.