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Circulating plasma factors involved in rejuvenation.
Jae Sook Kang1,2, Yong Ryoul Yang1
1Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Aging
|November 16, 2020
Summary
Young plasma contains rejuvenating factors that counteract aging and restore organ function in older individuals. Research identifies these factors, suggesting potential therapies for age-related diseases.
Area of Science:
- Gerontology and regenerative medicine.
- Molecular biology and aging research.
Background:
- Aging is a natural process involving functional decline across physiological systems.
- Age-related functional decline increases susceptibility to major diseases like cancer, cardiovascular, metabolic, and neurodegenerative disorders.
- Young blood plasma has shown rejuvenating effects in parabiosis experiments, indicating the presence of beneficial factors.
Purpose of the Study:
- To review current findings on rejuvenating factors present in plasma.
- To explore the potential of these factors in counteracting aging and treating age-related diseases.
Main Methods:
- Analysis of plasma protein levels in young versus old mice.
- Identification of specific rejuvenating factors through various experimental approaches.
- Review of existing literature on parabiosis and plasma-based rejuvenation.
Main Results:
- Numerous plasma proteins show significant level differences between young and old individuals.
- Several identified rejuvenating factors can reverse age-related impairments in different tissues.
- Young plasma administration counteracts aging effects and rejuvenates organs in aged mice.
Conclusions:
- Rejuvenating factors in plasma hold therapeutic potential for promoting repair and preventing degeneration in aging.
- Targeting these factors could lead to novel strategies for managing age-related diseases.
- Further research is warranted to harness the full potential of rejuvenating factors for human health.
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