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MicroRNA-149: A review of its role in digestive system cancers

Ning Wang1, Peng Zhou1, Yigang Chen1

  • 1Department of General Surgery, The Affiliated Wuxi NO.2 People's Hospital of Nanjing Medical University, Wu Xi, Jiangsu, China.

Pathology, Research and Practice
|November 16, 2020
PubMed

Insights

MicroRNAs (miRNAs), including microRNA-149 (miR-149), are crucial in cancer development. This review highlights miR-149

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are short, non-coding RNAs regulating gene expression, impacting cellular processes and disease.
  • miRNAs are implicated in tumorigenesis and cancer progression, acting via gene transcription regulation.
  • MicroRNA-149 (miR-149) has emerged as a significant factor in digestive system cancers.

Purpose of the Study:

  • To review recent findings on miR-149 in digestive system cancers.
  • To discuss miR-149's role, including its polymorphisms, expression, targets, and clinical significance.

Main Methods:

  • Literature review of recent studies on miR-149 in digestive system cancers.
  • Synthesis of data concerning miR-149's single nucleotide polymorphisms, expression levels, and target genes.
  • Analysis of miR-149's association with drug sensitivity and clinical outcomes.

Main Results:

  • miR-149 exhibits a pivotal role in the pathogenesis of digestive system cancers.
  • miR-149 functions as a potential diagnostic marker and therapeutic target in these cancers.
  • The review covers miR-149's polymorphisms, expression patterns, target genes, and clinical relevance.

Conclusions:

  • miR-149 is a key player in digestive system cancer development and progression.
  • miR-149 holds promise as a biomarker for diagnosis and a target for therapy in digestive cancers.
Keywords:
Diagnostic markerDigestive system cancersDrug sensitivityMiR-149

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