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Updated: Nov 30, 2025

Creation of Reversible Cholestatic Rat Model
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Staphylococcus aureus Skin and Soft Tissue Infection Recurrence Rates in Outpatients: A Retrospective Database Study

Venanzio Vella1, Ilaria Galgani1, Letizia Polito1,2

  • 1GSK, Siena, Italy.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|November 16, 2020
PubMed
Summary

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This summary is machine-generated.

Recurrent Staphylococcus aureus skin and soft tissue infections (SA-SSTIs) are common in healthy adults, affecting at least 1 in 6 individuals within a year. Understanding recurrence patterns is key for developing effective prevention strategies.

Area of Science:

  • Infectious Diseases
  • Dermatology
  • Epidemiology

Background:

  • Staphylococcus aureus skin and soft tissue infections (SA-SSTIs) are prevalent in healthcare and community settings.
  • Recurrences of SA-SSTIs are frequent, even after initial treatment, posing a significant clinical challenge.
  • Quantifying the burden and timing of recurrent SA-SSTIs is crucial for intervention planning.

Purpose of the Study:

  • To determine the incidence and timing of recurrent Staphylococcus aureus skin and soft tissue infections (SA-SSTIs).
  • To analyze recurrence patterns in patients with and without key comorbidities.
  • To provide data for evaluating and developing strategies to prevent SA-SSTI recurrence.

Main Methods:

  • Retrospective cohort study analyzing SSTI cases from 2006-2016 across three US medical centers.
Keywords:
Staphylococcus aureusSSTI recurrenceantimicrobial resistancemethicillin-resistant Staphylococcus aureusskin and soft tissue infection (SSTI)

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  • Inclusion of patients aged ≥18 years with index SSTIs, categorized as SA-SSTI or not microbiologically tested (NMT-SSTI).
  • Follow-up for 12 months to record recurrent infections, time to first recurrence, and number of recurrences.

    • Main Results:

    • Across centers, 16.4%-19.0% of SA-SSTI index cases and 11.0%-19.2% of NMT-SSTI cases experienced ≥1 recurrence.
    • In patients without key comorbidities, over 60% of recurrent SSTIs had only one recurrence.
    • Half of these single recurrences occurred within the first three months post-primary infection.

    Conclusions:

    • Recurrences of SA-SSTIs are common in healthy adults, with at least 1 in 6 experiencing recurrence within one year.
    • The findings highlight the need for effective interventions to manage and prevent SA-SSTI recurrence.
    • Early recurrence within three months is a significant pattern observed in patients without comorbidities.