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Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Venous Thrombosis IV: Nursing Management01:30

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Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Related Experiment Video

Updated: Nov 30, 2025

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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How I manage cyclic thrombocytopenia.

Paul A Kyrle1,2, Sabine Eichinger1,2

  • 1Department of Medicine I, Medical University of Vienna, Vienna, Austria; and.

Blood
|November 16, 2020
PubMed
Summary

Cyclic thrombocytopenia (CTP) is a rare disorder with fluctuating platelet counts, often misdiagnosed as immune thrombocytopenia (ITP). Early diagnosis through platelet monitoring prevents unnecessary ITP treatments.

Area of Science:

  • Hematology
  • Rare Diseases
  • Internal Medicine

Background:

  • Cyclic thrombocytopenia (CTP) is a rare hematological disorder.
  • CTP is characterized by periodic fluctuations in platelet counts.
  • The pathogenesis of CTP remains largely unknown and is considered heterogeneous.

Purpose of the Study:

  • To highlight the diagnostic challenges in CTP.
  • To emphasize the importance of accurate diagnosis to avoid inappropriate treatments.
  • To describe the clinical presentation and potential associations of CTP.

Main Methods:

  • Diagnosis of CTP relies on frequent platelet count monitoring.
  • Identifying a characteristic pattern of periodic platelet cycling is key.
  • Distinguishing CTP from primary immune thrombocytopenia (ITP) is crucial.

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Main Results:

  • Patients with CTP are frequently misdiagnosed with ITP, leading to years of diagnostic delay.
  • Inappropriate treatments for ITP, such as corticosteroids or splenectomy, yield transient platelet count increases wrongly attributed to treatment efficacy.
  • Bleeding in CTP is typically mild and mucocutaneous, occurring at the nadir of platelet count.

Conclusions:

  • Early and accurate diagnosis of CTP is essential to prevent exposure to potentially harmful therapies.
  • While some patients may respond to cyclosporine A or danazol, most CTP cases do not respond to conventional treatments.
  • CTP can be associated with hematological malignancies or thyroid disorders, and spontaneous remissions are possible.