Related Experiment Video

Updated: Nov 30, 2025

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery
06:03

Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery

Published on: September 30, 2021

5.3K

Paediatric pancreatic diseases

Michael J Coffey1, Chee Y Ooi1,2,3

  • 1Discipline of Paediatrics, School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.

Journal of Paediatrics and Child Health
|November 16, 2020
PubMed

Insights

Pediatric pancreatic diseases, including pancreatitis and exocrine pancreatic dysfunction, are often missed but have serious consequences. Recent research advances are improving recognition and management of these childhood conditions.

Area of Science:

  • Pediatric Gastroenterology
  • Pancreatology
  • Clinical Research

Background:

  • Paediatric pancreatic diseases are frequently underdiagnosed.
  • These conditions can lead to severe health issues and significant clinical outcomes in children.
  • International collaborations are advancing research in this field.

Purpose of the Study:

  • To review key advancements in understanding paediatric pancreatic diseases.
  • To focus on the two primary manifestations: pancreatitis and exocrine pancreatic dysfunction in childhood.
  • To highlight recent progress driven by international research efforts.

Main Methods:

  • Literature review of recent studies on paediatric pancreatic diseases.
  • Synthesis of findings from international societies and study groups.
  • Focus on clinical manifestations, diagnosis, and management.

Main Results:

  • Paediatric pancreatitis and exocrine pancreatic dysfunction are significant concerns.
  • Advances in research have enhanced the understanding of these conditions.
  • Improved diagnostic and therapeutic strategies are emerging.

Conclusions:

  • Early recognition and management of paediatric pancreatic diseases are crucial.
  • Continued research is vital for improving outcomes for children with these disorders.
  • This review provides an overview of current knowledge and future directions.

Keywords:
childcystic fibrosisexocrine pancreatic insufficiencypancreatic diseasespancreatitispancreatitis chronic

More Related Videos

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.2K
Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis11:07

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: September 5, 2025

644

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
516
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
192
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
97
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
511
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
128
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
925