Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling.

Nature medicine·2026

Same author

Pathological phimosis is associated with foreskin immune cell infiltration but not microbiota composition.

mSphere·2026

Same author

Prebiotic modulation of FMT donor microbiota enhances MASLD-relevant taxa and functions in an in vitro gut model.

Journal of applied microbiology·2026

Same author

Chronic exercise training intensity, immune cells, and cancer outcomes: a scoping review.

JNCI cancer spectrum·2026

Same author

Fecal microbiota transplantation plus immunotherapy in metastatic renal cell carcinoma: the phase 1 PERFORM trial.

Nature medicine·2026

Same author

Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial.

Nature medicine·2026

Search research articles

Related Experiment Video

Updated: Nov 30, 2025

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

Immunomodulation in Pancreatic Cancer.

Mithunah Krishnamoorthy^1,2, John G Lenehan³, Jeremy P Burton^1,4,5

¹Department of Microbiology and Immunology, University of Western Ontario, London, ON N6A 3K7, Canada.

|November 17, 2020

Summary

Pancreatic cancer survival may improve by activating T-cells, crucial for anti-tumor immunity. This review explores immune strategies to enhance pancreatic cancer treatment effectiveness.

Keywords:

T-cells anti-PD1 fecal microbiota transplant immunotherapy microbiome pancreatic cancer pancreatic ductal carcinoma

More Related Videos

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Immunophenotyping of Orthotopic Homograft Syngeneic of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Immunophenotyping of Orthotopic Homograft Syngeneic of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Published on: October 9, 2018

Related Experiment Videos

Last Updated: Nov 30, 2025

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Immunophenotyping of Orthotopic Homograft Syngeneic of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Immunophenotyping of Orthotopic Homograft Syngeneic of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Published on: October 9, 2018

Area of Science:

Oncology
Immunology
Microbiology

Background:

Pancreatic cancer exhibits high mortality and increasing incidence globally.
Late-stage symptom presentation and limited treatment options contribute to poor prognosis.
Current immune checkpoint inhibitors are ineffective for pancreatic cancer.

Purpose of the Study:

To review immunological mechanisms driving anti-tumor immunity in pancreatic cancer.
To explore immune-based strategies for novel pancreatic cancer treatments.

Main Methods:

Review of existing literature on pancreatic cancer immunology.
Analysis of factors associated with long-term survival in pancreatic cancer patients.
Investigation of T-cell activation and bacterial species in tumor microenvironments.

Main Results:

Long-term survivors show increased cytotoxic T-cell infiltration.
Specific bacterial species correlating with T-cell activation are identified in tumors.
T-cell activation is suggested as essential for anti-tumor immunity.

Conclusions:

Targeting T-cell activation presents a promising avenue for pancreatic cancer therapy.
Understanding tumor immunology can guide the development of effective immune-based treatments.