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Interface between adaptive and neoplastic growth in the pancreas
1Dartmouth Medical School, Hanover, NH.
Gut
|January 1, 1987
Summary
Pancreatic growth responses, including adaptive changes and early neoplastic growth, are influenced by hormones like cholecystokinin (CCK). These factors impact cancer development probability.
Area of Science:
- Pancreatic physiology and oncology
- Cellular growth regulation
Background:
- Adaptive pancreatic changes like hypertrophy and hyperplasia are reversible responses to growth stimuli.
- Early neoplastic pancreatic growth involves clonal progression through preneoplastic lesions.
Purpose of the Study:
- To investigate the role of hormones and growth factors in pancreatic neoplastic development.
- To understand the progression from preneoplastic lesions to pancreatic cancer.
Main Methods:
- Studied carcinogen-treated animal models.
- Identified preneoplastic lesions such as atypical acinar cell foci, nodules, and ductal complexes.
Main Results:
- Neoplastic pancreatic growth is clonal, progressing through multiple steps.
- Hormones like cholecystokinin (CCK) stimulate both adaptive and neoplastic pancreatic growth.
- Progression rate to cancer can be modulated by factors controlling adaptive growth.
Conclusions:
- Hormonal growth factors significantly influence the development of pancreatic cancer.
- Understanding these factors is crucial for predicting and potentially preventing pancreatic carcinoma.
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