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Preeclampsia as chronic disseminated intravascular coagulation. Study of two parameters: thrombin-antithrombin III

T Kobayashi1, T Terao

  • 1Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan.

Gynecologic and Obstetric Investigation
|January 1, 1987
PubMed

Insights

Preeclampsia is characterized by chronic disseminated intravascular coagulation (DIC). This study shows increased thrombin-antithrombin III complex (TAT) and D-dimers, with decreased antithrombin III (ATIII) and platelets, confirming DIC in preeclampsia.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Pathophysiology

Background:

  • Normal pregnancy exhibits a hypercoagulative state with thrombin formation.
  • Thrombin is typically inactivated by antithrombin III (ATIII), preventing fibrin formation.
  • Increased thrombin-antithrombin III complex (TAT) reflects this inactivation in normal pregnancy.

Purpose of the Study:

  • To investigate if preeclampsia represents a chronic disseminated intravascular coagulation (DIC) state.
  • To analyze coagulation and fibrinolysis parameters in preeclampsia.
  • To differentiate preeclampsia's coagulation profile from normal pregnancy.

Main Methods:

  • Measured thrombin-antithrombin III complex (TAT) and D-dimers.
  • Assessed antithrombin III (ATIII) levels, fibrin degradation products, and platelet counts.
  • Compared coagulation parameters between preeclamptic and normal pregnancies.

Main Results:

  • Preeclampsia showed increased TAT and D-dimers.
  • Antithrombin III (ATIII) levels and platelet counts were decreased in preeclampsia.
  • These findings indicate a chronic DIC state in preeclampsia, distinct from acute DIC.

Conclusions:

  • Preeclampsia exhibits a chronic disseminated intravascular coagulation (DIC) profile.
  • The observed changes in TAT, D-dimers, ATIII, and platelets strongly support the DIC nature of preeclampsia.
  • This study provides clearer evidence for the chronic DIC state in preeclampsia than previous research.

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