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Updated: Nov 30, 2025

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

8.2K

Tyrosine Kinase Receptors in Oncology

Jorge Esteban-Villarrubia1, Juan José Soto-Castillo1, Javier Pozas1

  • 1Medical Oncology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain.

International Journal of Molecular Sciences
|November 17, 2020
PubMed

Insights

Tyrosine kinase inhibitors (TKIs) offer targeted cancer treatment by blocking tyrosine kinase receptors (TKRs) involved in tumor growth. This review explores TKR families, their role in cancer, and TKI therapies for precision oncology.

Area of Science:

  • Molecular Biology
  • Oncology
  • Pharmacology

Background:

  • Tyrosine kinase receptors (TKRs) are crucial cell signaling molecules.
  • Genetic alterations in TKRs are implicated in cancer development and tumorigenesis.
  • Tyrosine kinase inhibitors (TKIs) represent a significant advancement in molecularly targeted cancer therapy.

Purpose of the Study:

  • To comprehensively review TKR families and their function in tumor cell expansion.
  • To elucidate the mechanisms by which TKIs inhibit TKR-driven tumorigenesis.
  • To discuss the role of TKIs in combination therapies and the future of precision oncology.

Main Methods:

  • Literature review of scientific publications on TKRs and TKIs.
  • Analysis of TKR signaling pathways in various cancer types.
  • Evaluation of clinical trial data for TKI efficacy and combination strategies.

Main Results:

  • TKRs regulate essential pathways for cell survival and differentiation, with alterations driving cancer.
  • TKIs effectively target specific TKRs, interrupting oncogenic signaling cascades.
  • TKIs show promise in monotherapy and combination treatments, advancing precision oncology.

Conclusions:

  • Understanding TKR families and their inhibitors is vital for cancer treatment.
  • TKIs are a cornerstone of molecularly targeted cancer therapy.
  • The shift towards molecular-based therapy in clinical trials signifies a move towards more effective precision oncology.
Keywords:
researchtumorigenesistyrosine kinase receptor inhibitorstyrosine kinase receptors

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