Related Experiment Video
Updated: Jul 16, 2026
11:42
Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
25.1K
D-10-camphorsulfonic acid: Safety evaluation
Markus Fehr1, Ádám Appl2, David J Esdaile2
1DSM Nutritional Products, Wurmisweg 576, 4303 Kaiseraugst, Switzerland.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis
|November 17, 2020
Summary
D-10-camphorsulfonic acid (CSA) is safe, showing no genotoxicity in Ames and micronucleus tests. A 90-day rat study found no adverse effects, establishing a high safety margin for consumers.
Area of Science:
- Toxicology
- Pharmacology
- Food Safety
Background:
- D-10-camphorsulfonic acid (CSA) is used in animal feed.
- Comprehensive safety evaluations are crucial for feed additives.
Purpose of the Study:
- To assess the genotoxicity of CSA.
- To determine the safety profile of CSA through a 90-day subchronic study in rats.
- To establish a no-observed-adverse-effect level (NOAEL) for CSA.
Main Methods:
- Genotoxicity was evaluated using the Ames test and in vitro micronucleus test.
- Rats were administered CSA in drinking water for 90 days at various doses.
- Macroscopic and clinical signs were monitored during the study.
Main Results:
- Genotoxicity tests for CSA were negative.
- No mortality or adverse clinical signs were observed in rats during the 90-day study.
- The no-observed-adverse-effect level (NOAEL) was determined to be 0.20 mg/mL (25 mg/kg bw/day).
Conclusions:
- CSA demonstrated no genotoxic potential.
- CSA is safe for consumption, with a NOAEL significantly higher than estimated human exposure levels.
- The safety margin supports the use of CSA as a feed additive.
