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Gallium-Based Liquid Metal Particles for Therapeutics.

Wanjie Xie1, Francois-Marie Allioux1, Jian Zhen Ou2

  • 1School of Chemical Engineering, University of New South Wales, Kensington, NSW 2052, Australia.

Trends in Biotechnology
|November 17, 2020
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Summary

Gallium-based liquid metal particles offer unique fluidic and metallic properties for advanced therapeutics. This review highlights recent advances and future opportunities in their design and application for drug delivery and cancer treatment.

Keywords:
galliumliquid metal particlestherapeutics

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Area of Science:

  • Biotechnology and Biomedical Engineering
  • Materials Science
  • Nanomedicine

Background:

  • Gallium (Ga) and liquid metal (LM) alloys possess low toxicity, high conductivity, and room-temperature fluidity.
  • Ga-based LM particles (LMPs) combine fluidic and metallic traits, enabling versatile functionalization for therapeutic applications.
  • Current understanding of Ga-based LMPs' therapeutic potential remains incomplete.

Purpose of the Study:

  • To review recent advancements in Ga-based LMPs for therapeutic applications.
  • To elucidate the underlying mechanisms of Ga-based LMP design and implementation in medicine.
  • To explore future biotechnological opportunities for these unique particles.

Main Methods:

  • Review of recent scientific literature on Ga-based liquid metal particles in therapeutics.
  • Analysis of design principles and implementation strategies for functionalized Ga-based LMPs.
  • Exploration of actuation mechanisms (physical/chemical stimuli) for targeted delivery and treatment.

Main Results:

  • Ga-based LMPs demonstrate potential in drug delivery, cancer treatment, bioimaging, and biosensing.
  • Functionalized LMPs can be precisely controlled using external stimuli for enhanced therapeutic efficacy.
  • The unique properties of Ga-based LMPs offer significant advantages over traditional therapeutic agents.

Conclusions:

  • Ga-based LMPs represent a promising platform for next-generation nanomedicine.
  • Further research into their fundamental characteristics will unlock broader therapeutic applications.
  • Continued development holds potential for innovative biotechnological solutions in healthcare.